Nanolive 3DCX-fluo and 3DCX-discovery microscopes for live cell imaging

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Nanolive, the creator of the holographic tomographic 3D Cell Explorer (3DCX), has expanded its family of microscopes to include two more systems.

The original 3DCX allows users to see inside cells, using variations in refractive index within the sample, without the need for stains, dyes or markers — a completely label-free system for high-resolution 3D and 4D cell imaging. The technology allows users to visualise subcellular structures in real time, offering 200 nm resolution and generating 3D reconstructions from 96 slices through a 30 µm-thick sample.

The recently released 3DCX-fluo offers the same powerful holo-tomographic microscopy but adds a fluorescence channel. This enables users to measure up to 10 channels, including overlaying refractive index data, with up to three fluorescence channels and with the option of adding a stage top incubator for time-lapse experiments. This can reveal more information than conventional fluorescence microscopy, according to the company, by combining physical structural imaging (refractive index) with functional information about organelles, proteins and drugs interacting within the cell (fluorescence).

The latest addition to the Nanolive family is the 3DCX-discovery, designed for teaching environments. Based on the original 3DCX, the 3DCX-discovery is a plug-and-play system capable of providing high-quality images with nanometric resolution in just seconds, with minimal sample preparation. Without the need for markers, stains or dyes, the product is a powerful teaching tool and a suitable introduction to imaging live cells in real time.

For more information: http://www.axt.com.au/nanolive-family/.