Tomocube HT-X1 Plus Holotomography system

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The HT-X1 Plus Holotomography system extends the reach of holotomography to an even broader array of challenging specimens — including dense organoids, tissue sections and fast-moving microorganisms. The state-of-the-art bioimaging platform is designed to empower researchers with the precision, efficiency and reliability needed for applications in 3D biology, immunology, regenerative medicine and cell biology.

Equipped with a high-spec sCMOS camera featuring a 4x larger field of view and reduced acquisition time compared to previous models, the HT-X1 Plus can be used for high-throughput phenotypic screening of cells and organoids without the need for stitching. Its upgraded correlative imaging capabilities — incorporating a sCMOS-based fluorescence module — enable seamless integration of molecular studies with single-cell-resolution 3D images. Users can experience clear, detailed imaging of multi-layered specimens with improved illumination optics and advanced image reconstruction algorithms. Imaging can be customised with three wavelength options to enhance contrast or improve penetration.

The system offers high content screening of live cells and organoids, making it suitable for high-content, image-based drug screening research. High-resolution imaging of 3D biological samples is especially advantageous for research involving 3D cultures, enabling the detailed investigation of dense organoids and intact tissue sections. Enhanced correlative fluorescence imaging is possible with the fluorescence module (FLX), featuring an sCMOS camera designed specifically for precise signal intensity measurements. With the colour brightfield imaging modality and wide preview scan features, researchers can gain deep insights into histological tissue section studies.