Bruker maXis, ultrafleXtreme, amaZon and solariX

Bruker Daltonics has released its latest life science mass spectrometry tools.

The maXis high-speed, high-resolution TOF (UHR-TOF) mass spectrometer for small molecule and proteomics applications has been enabled with ETD, a technique to improve how users study protein primary and secondary structures, modifications, folding and function.

The ultrafleXtreme is claimed to be the only fully 1 kHz MS and MS/MS-enabled Maldi-TOF/TOF system available. With smartbeam-II laser technology and a 4 GHz digitiser, its proteomics performance shows broad-band mass resolving power up to 40,000 and 1 ppm mass accuracy. It allows LC-MALDI TOF/TOF, label-free quantitation, top-down intact protein analysis, Edmass protein sequencing, polymer characterisation and oligonucleotide analysis.

Its rapid self-cleaning ion source imaging software and laser focal diameters down to 10 µm are claimed to deliver the most complete MALDI imaging system on the market. The integration of the Carl Zeiss Mirx Virtual Slide Scanner has enabled advances in non-targeted molecular histology with high spatial resolution (research use only).

amaZon is claimed to be the fastest ion trap available with a 52,000 µ/s scan rate at 0.58 µ mass resolution. The integration of dual-ion funnel technology has increased sensitivity by an order of magnitude and the ETD/PTR module for proteomics offers good ETD sensitivity. A mass resolving power up to 20,000 in full scan mode across m/z 50-3000 enables top-down ETD experiments. An MS data acquisition speed of 20 Hz with zero-delay polarity switching makes it suitable for all fast-screening applications based on spectral libraries, including clinical toxicology and forensics.

The solariX hybrid FTMS system is said to deliver a 10-fold improvement in sensitivity, an 8-fold gain in broadband ultra-high resolution (>1,000,000 at 7 T) and sub-ppm mass accuracy over a wide dynamic range. With both ETD and ECD proteomics tools included, solariX is suitable for analysis of complex mixtures in top-down proteomics. Applications also include petroleomics, metabolomics and small-molecule drug and metabolite Maldi imaging on the dual ESI/MALDI source system.

Its 18 T magnet, designed for FTMS applications, is said to represent the world’s highest field FTMS magnet, providing scientific capabilities suitable for complex and challenging protein, polymer and small molecule analyses.