JASCO high-throughput circular dichroism (HTCD) system

Circular dichroism (CD) is a staple technique used in biochemistry to determine the structure of proteins and peptides, study intermolecular interactions with substrates and monitor the stability of molecules as a function of pH or temperature.

Newer applications, such as food analysis, material characterisation and vaccine development, are possible due to the high-quality optical design of the JASCO J-1000 series CD instruments and the various software packages available.

The JASCO high-throughput CD (HTCD) configuration brings together automated sample handling, cleaning and data analysis. The autosampler can accommodate two 96-well plates to churn through large sample sets, the capability to import worklists for automated data analysis and management, and optional CFR 21 part 11 compliant software to maintain data integrity. With its simple operation, the instrument is suitable for scientists working in the pharmaceutical, process and biotechnology or food chemistry sectors.

The research-grade J-1500 and J-1700 instruments sit at the core of the HTCD configuration, enabling the HTCD to fit into multiple positions within a laboratory workflow, such as R&D (drug development), scale-up efficiency (monitoring manufacturing processes) and quality control (analysis of end products).

Software and applications are continually growing into sectors like vaccine development (Moderna COVID-19 vaccine) and drug discovery (therapeutic antibodies). Users do not have to be experts in CD spectroscopy to operate, analyse and understand what the data is showing.

Bio-Strategy provides end-to-end support, ranging from method development and application support to service and maintenance.