NanoString Technologies CosMx Spatial Molecular Imager

NanoString Technologies’ CosMx SMI is a spatial biology platform that maps individual RNA and/or protein molecules on a tissue section with subcellular 3D resolution. It enables rapid quantification and visualisation of up to 1000 RNA and 100 validated protein analytes.

The product is a flexible spatial single-cell solution driving deep insights into the cell atlas, cell–cell interaction, cellular processes and biomarker discovery. It is an integrated system with mature cyclic fluorescent hybridisation (FISH) chemistry, high-resolution imaging readout, and interactive data analysis and visualisation software.

The device is a flexible and robust spatial biology solution for applications including: cell atlas and characterisation (defining cell types, cell states, tissue microenvironment phenotypes and gene expression networks within spatial context); cell–cell interaction (understanding biological process controlled by ligand–receptor interactions); and spatial biomarkers (quantifying change in gene expression based on treatment and identify single-cell subcellular biomarkers with spatial context).

Pre-release access to CosMx SMI technology is available through NanoString’s Technology Access Program (TAP), enabling comprehensive answers with 1000-plex RNA assays in a single experiment using a wide range of sample types, including FFPE biopsy and fresh-frozen tissue sections.