Postnova Analytics AF2000 MALS system

Postnova Analytics announces the AF2000 MALS — a temperature-controlled system developed to provide good separation, characterisation and fractionation of biopharmaceutical proteins.

The system employs a similar set-up to a traditional GPC-MALS system but avoids the limitations of column-based chromatographic separations. The liquid chromatography column is replaced by a separation channel technology that retains molecules based only on size and by the influence of a crossflow as a separation force. Because of the design of the system and the absence of any stationary phase, separation is achieved without exerting shear forces and stress on the proteins and aggregates being separated.

Incorporating multiangle light scattering (MALS) and asymmetric flow field-flow fractionation (AF4), the product offers separation over a broad molar mass and particle size range. With the additional benefit of being able to undertake precisely temperature-controlled experiments, the unit is able to achieve separations with high resolution, reproducibility and recovery.