SCIEX ZenoTOF 7600+ system

SCIEX is advancing its high-resolution accurate mass spectrometry portfolio with the launch of the ZenoTOF 7600+ system.

As the latest addition to the ZenoTOF line, the product features the ZT Scan DIA strategy, leveraging the combination of the quadrupole dimension with the rich MS/MS data achievable from the Zeno trap. The system aims to address a research gap — simplifying the transition of protein biomarker candidates beyond the discovery stage.

The inclusion of ZT Scan DIA, the latest evolution of data independent acquisition, means the system encompasses a multi-acquisition combination of DDA, DIA and targeted approaches within a single workflow. Results are achieving over 125% more quantifiable protein groups at sub-nanogram levels than conventional discrete-window DIA, according to the company.

Scanning speeds of up to 640 Hz make this the fastest SCIEX accurate mass system, increasing the scope for large quantitation panels. Electron activated dissociation (EAD) meanwhile offers tunable fragmentation of all molecule types, further extending analytical capabilities.

The system maps the MS/MS scans with the scanning Q1 quadrupole dimension, to further increase confidence for the differentiation of isomeric peptides and localise post-translational modifications (PTMs). It also offers flexibility of acquisition by allowing DDA, DIA and MRMHR using CID, EAD or both fragmentation modes.

SCIEX has announced three strategic collaborations that work to further propel key proteomics capabilities, meaning the system is compatible with the PEAKS 12.5 from Bioinformatics Solutions, the Evosep One from Evosep and the Aurora Series XS Range from IonOpticks. DIA analysis using DIA-NN is also fully supported.