Thermo Scientific AccelerOme Automated Sample Preparation Platform

Thermo Fisher Scientific is looking to help proteomics researchers increase productivity and free up time for more value-added activities when generating high-quality samples for analysis, using an automated sample preparation system that integrates within any LC-MS workflow.

The Thermo Scientific AccelerOme Automated Sample Preparation Platform eliminates the need for labour-intensive, manual sample preparation for LC-MS analysis, including the associated method development and reagent sourcing. This allows users to focus on higher value tasks. Automated sample preparation also overcomes the challenge of maintaining reproducibility with manual methodologies, and the platform’s pre-built validated methods and kit format reagents should reduce further any risk of user error. The resulting peptide samples are of consistent high quality.

A novel built-in UV measurement of final peptide concentration prior to LC-MS analysis allows the standardisation of sample peptide input for LC-MS analysis — another metric that adds to the quality and robustness of the final experimental result. The platform supports the use of peptide standards to monitor LC-MS system performance, enabling instrument health monitoring during acquisition or through post-acquisition data analysis.

The sample preparation platform, designed with an experimental design tool, combines reproducible hardware with easy-to-use software and commercially available reagent kits for both label-free and TMT multiplexing applications. A software wizard guides users through each step, facilitating proteomics research to newcomers to the field. The platform is optimised to fit into the Thermo Scientific Orbitrap MS ecosystem. End-to-end software, sample and study factor information are transferred from sample input all the way through to LC-MS acquisition through data analysis with Thermo Scientific Proteome Discoverer Software.