Thermo Scientific Exploris 480 benchtop mass spectrometer

Thermo Scientific’s Orbitrap Exploris 480 is a compact benchtop mass spectrometer that unlocks the power of an advanced differential ion mobility interface option and internal standard-triggered methods, to deliver high levels of performance in high-throughput laboratory environments. It is designed for advanced protein analysis, quantitative proteomics and small molecule applications for biopharmaceutical and translational research scientists. It uses intelligence-driven data acquisition strategies to carry out rigorous, high-throughput protein identification, quantitation and structural characterisation of biotherapeutics and translational biomarkers.

The system provides enhanced quantitative performance across label-free and tandem mass tag (TMT) experiments, as well as access to Thermo Scientific SureQuant methods for ultrasensitive targeted protein assays. This combination allows researchers to conduct rapid, multiplexed analysis of proteins within complex biological matrices. With a smaller footprint than previous generations, the system maximises laboratory bench space while maintaining high resolution and spectral quality. Additionally, the MS has many features to extend uptime and improve serviceability for researchers in high-throughput laboratory environments.

Users will experience the immediate convenience and benefits of a common method programming interface and sources, shared with Thermo Scientific Tribrid and Triple-stage Quadrupole (TSQ) instruments. For example, the MS takes full advantage of the Thermo Scientific FAIMS Pro interface, which can boost the already-extensive proteome coverage of the instrument by 20%. Users will also benefit from the ability to analyse a wide range of compounds, enabled by a wide mass range of 40 to 6000 m/z (with the option to increase the range to 8000 m/z using the BioPharma mode).

The mass spectrometer can easily be integrated into a laboratory’s routine workflows with the Thermo Scientific Almanac web-based application, which allows users to view instrument operation and data acquisition in real time and receive notifications on the status of runs. This offers scientists the convenience of improved visibility to the utilisation of their laboratory systems, no matter how busy they are or where they are.