Thermo Scientific ISQ EM single quadrupole mass spectrometer

Chromatographers looking for confidence in their samples can now benefit from a single quadrupole mass spectrometer designed for ease of use while offering application flexibility for challenging mass confirmation analyses.

Driven by industry demand for a robust, easy-to-implement system, Thermo Fisher Scientific designed the Thermo Scientific ISQ EM single quadrupole mass spectrometer for high performance and productivity standards in laboratories. With a mass range of 10–2000 m/z, the system offers the power to detect and quantify small and large molecules, and supports analytical needs across an extensive range of applications — from drug development to manufacturing support and quality control. The system’s high-performing heated electrospray ionisation (HESI) and dual HESI/atmospheric pressure chemical ionisation (APCI) probes facilitate the measurement of polar and non-polar analytes, enabling application flexibility.

The product was designed to enable novice and expert mass spectrometry users to take advantage of LC-MS’s good sensitivity and selectivity for the rapid analysis of complex sample matrices. It allows scientists to obtain substantial information from routine samples and thereby permits single-assay runs, tracks emerging impurities and quickly confirms the mass of newly synthesised entities.

The device is integrated with the HPLC and fully controlled by Thermo Scientific Chromeleon Chromatography Data System (CDS), which offers tools to guide users through LC-MS method development and select appropriate source conditions. Thermo Scientific Chromeleon XPS Open Access software also supports the ISQ EM with walk-up workflows for simple daily operation. Additionally, full integration with native control in Chromeleon CDS enables users to benefit from the entire productivity suite, from method creation through final reporting. A built-in reference standard also automates instrument calibration for a user-friendly experience.