Triple quadrupole LC-MS/MS system

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The Thermo Scientific TSQ Vantage is the Thermo Scientific’s flagship triple quadrupole LC-MS/MS system that delivers up to 10 times more sensitivity than any other triple quadrupole instrument on the market; it does not produce a commensurate increase in noise.

Technical breakthroughs have given the TSQ Vantage unmatched signal-to-noise performance, providing better reproducibility and precision in the quantitative analysis of small molecules, biomolecules and peptides, according to Thermo Fisher Scientific.

This system enables scientists working with small molecules, biomolecules or peptides to detect compounds at ultra low-quantitation levels and to do so reproducibly with great precision; doing anything less risks data integrity and potentially an entire drug study, according to Rohan Thakur, PhD, marketing director, Small Molecule Solutions, Thermo Fisher Scientific.

Many LC-MS/MS systems claim high sensitivity, but can only deliver on that promise by sacrificing precision, specificity and reproducibility because of high chemical noise levels. The TSQ Vantage offers up to 10 times the signal-to-noise ratio when compared to the TSQ Quantum series and, according to the company, it exceeds any other triple quadrupole instruments in the field. The instrument’s performance is due to technical innovations in ionisation efficiency and ion transmission.

The TSQ Vantage’s S-Lens ion optics system uses an electrostatic field technology to capture virtually every ion and efficiently transfer it into the HyperQuad quadrupole mass analyser. The S-Lens design is a significant advance over high-pressure, skimmer-based ion source designs, as it eliminates mass discrimination and lowers the gas load on the expensive turbo-molecular pumps. This innovation keeps the ion optical path cleaner, longer, while maintaining sensitivity.