Waters BioAccord System with ACQUITY Premier

Waters Corporation has introduced the Waters BioAccord System with ACQUITY Premier, a combination of the Waters BioAccord System and the breakthrough ACQUITY Premier UPLC with MaxPeak High Performance Surface (HPS) technology. The integrated, high-resolution LC-MS system is designed to simplify multi-attribute monitoring of biotherapeutics by improving analyte recovery and assay-to-assay reproducibility so that regulated laboratories can get needed medicines to patients quickly.

As promising as next-generation biotherapeutics are, they can be difficult to characterise when they contain low-level analytes which strongly interact and bind to the internal metal surfaces of conventional LCs, making them almost impossible to detect. By solving the problem of analyte-to-metal interactions, the system gives scientists a means of getting information about everything in their samples from the very first injection.

The compact benchtop system features MaxPeak HPS technology — a hybrid organic–inorganic surface technology that forms a barrier between the sample and the biocompatible metal surfaces of both the UPLC inlet and column — and the SmartMS-enabled ACQUITY RDa mass detector. This allows analysts of all abilities to monitor critical quality attributes of biotherapeutics and assess the processes that make them, all while decreasing risk, due to compliant-ready acquisition and data workflows that deliver consistent data quality from user to user and system to system.

With automated set-up and guided workflows made possible with SmartMS technology, the system is designed for easy deployment. Rapid system start-up is enabled through the delivery of​ system and applications training with pre-defined biopharmaceutical methods for each key workflow. Because regulatory compliance and data integrity is vital to many biopharmaceutical laboratories, the system is built on the waters_connect informatics platform backed by compliant informatics architecture and the worldwide availability of professional qualification services. ​