Shimadzu Nexera UHPLC Method Scouting System

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The Method Scouting System is based on the Shimadzu Nexera next-generation ultra high performance liquid chromatograph (UHPLC). It uses the specially developed Method Scouting Solution control software and a robust, high-pressure column switching system to switch mobile phases and columns automatically, achieving a quick and accurate method scouting workflow. As a result, this system provides strong support for efficient HPLC method development.

With Method Scouting Solution, just set the required conditions to create a scouting batch automatically. This saves time with respect to method creation, management and batch creation. By combining this system with the company’s HPLC workstation, LabSolutions, and using its browser functions, the numerous chromatograms obtained from method scouting can be quickly evaluated, thereby enhancing method development efficiency.

In a typical method scouting procedure, data is collected using a number of mobile phase and column combinations. But HPLCs switching manually between these combinations are limited by the number of work hours in a single day. The product is capable of automatically investigating up to 96 combinations of mobile phases and columns, without such time restrictions, thereby significantly improving method development productivity.

Mobile phase purge conditions and equilibration when automatically switching mobile phases and columns are key issues in method scouting. With the product’s software, the scouting process reflects laboratory operations, due to automatic control of mobile phase purging and equilibration based on preset system configurations. Scouting schemes can be set to give priority to columns or mobile phases based on laboratory policy.