Cayman LipiDOT Strips for protein–lipid interactions

Cayman Chemical has developed Cayman LipiDOT Strips as a research tool for the rapid identification of protein–lipid interactions. The tool allows researchers to maximise the information gained from early protein–lipid interaction screening campaigns, providing insight into protein–lipid interactions while being simple to perform and easily completed in a single day.

The strips can be used to identify one or more lipids interacting with a protein of interest, assess a protein’s relative lipid-binding specificity and/or identify protein candidates for in-depth lipid-binding analysis. By identifying new lipid–protein interactions, researchers can better understand the important roles of lipids in modulating protein function and gain important insights into the biology of diseases and biological processes, which may prove useful in the pursuit of new therapeutic avenues.

Cayman LipiDOT Strips - PIPs Plus is the first introduction to the product group, featuring 22 biologically relevant lipids arranged in a preconfigured panel. It contains several types of lipids, such as phospholipids, including a variety of phosphatidylinositol phosphate (PIP) species, lysophospholipids and cardiolipin, as well as cholesterol and sphingolipids. These lipids interact with a variety of proteins to regulate signalling events, nutrient and energy metabolism, lipid transport and cell adhesion, among other processes.

Custom biophysical characterisation and structural biology solutions are also provided by Cayman to further characterise protein–lipid interactions.