Clostridium difficile (C. difficile) is the causative agent of antibiotic-associated diarrhoea and pseudomembranous colitis. It produces two major exotoxins (toxin A and toxin B), which are the prototypes of the family of large clostridial cytotoxins. Some strains of C. difficile also produce a binary ADP-ribosylating toxin (CDT) which modifies actin. The pathogenic role of CDT binary toxin in diseases induced by C. difficile is not clear, but about 10% of strains isolated from patients with colitis contain CDT binary toxin genes.
List Labs manufactures highly purified native Clostridium difficile toxins: toxin A (TcdA) and toxin B (TcdB), for research use; TcdA is available lyophilised in buffer, whereas TcdB is available in a liquid formulation. They are distributed in Australia and New Zealand by Sapphire Bioscience.
Phone: 02 9698 2022
Cayman Chemical Natural Products Screening Library
Cayman Chemical's Natural Products Screening Library consists of 22 plates and contains...
AdipoGen Life Sciences DYRK inhibitors
Leucettinibs provide research tools and potential leads for further optimisation towards...
GroPep Bioreagents IGF-1 Family Proteins
IGF-1 proteins are available in different sizes, and all GroPep Bioreagents are freeze-dried and...
