TdB Labs dextran sulfate sodium (DSS) for colitis

The gold standard for colitis studies is dextran sulfate sodium (DSS), which is used to induce colitis in experimental animals. A concentration of 2–4% DSS in the drinking water has been shown to induce clinical symptoms in mice. The dosage in all experimental animals should also be adjusted in accordance with the requirements of the study — a milder onset of colitis or a more aggressive response.

DSS from TdB Labs have been used to study colitis for almost 30 years. Currently there are more than 300 published studies where DSS from TdB Labs have been used to induce colitis.

DSS for colitis is supplied as the sodium salt and is stabilised by a small addition of phosphate salts. A certificate of analysis is supplied with each batch. The molecular weight range, sulfur content, moisture, etc, are carefully controlled.