Single-molecule techniques manual

 Single-Molecule Techniques: A Laboratory Manual is a guide to help molecular and cellular biologists move towards nano-techniques for performing experiments on single molecules rather than on populations of molecules. It is claimed to take researchers who know nothing about single-molecule analyses to the point where they can successfully design and execute appropriate experiments.

Geared towards research scientists in structural and molecular biology, biochemistry and biophysics, the manual is suitable for all who are interested in observing, manipulating and elucidating the molecular mechanisms and discrete properties of macromolecules.

Techniques range from in vivo and in vitro fluorescent-based methods to the use of atomic force microscopy, optical and magnetic tweezers and nanopores.

The book is edited by Paul R Selvin and Taekjip Ha, two pioneers in the field of experimental biophysics who have made contributions to the development and application of single-molecule technologies.