Customised biomedical clinical analysis for blood samples

In clinical diagnostics, reliability and precision are essential. In the development of analytical devices for in vitro diagnostics laboratories, Spanish company BioSystems S.A. aims to maximise cost efficiency and flexibility. To meet all requirements, BioSystems worked closely with Bürkert Systemhaus as a development partner. This gave rise to a unique customer solution for the dosing of various media, which also satisfies the highest precision requirements.

Since 1981, BioSystems has been committed to offering effective analytical systems to laboratories around the world. The company’s facilities in Barcelona house a young and highly qualified team of researchers and microfluidic engineers that produce a wide variety of instruments and reagents of high quality for their customers. They strive to deliver equipment that is precise but also offers cost efficiency and flexibility for their customers.

When customising its biomedical clinical analysis system, the challenge for BioSystems was to innovate the dosing mechanism for liquids in a blood analysis system. The project was based on the requirements for BioSystems’ customers to have a very high dosing precision device fit into an extremely compact space, while maintaining precision measurement, regulation and control of the flow rates — all the while saving costs without compromising on quality.

BioSystems and Bürkert had a trusted and long-term relationship, and together their teams worked on a solution that met the required challenges of innovating the analysis system solution for existing and future BioSystems customers. The result was the BA-400 biochemical analysis device.

Bürkert developed a modular dosing unit that incorporates various components: two or three valves, a pressure sensor and a filter on a transparent plastic injection unit. The fluid experts not only provided a solution to effectively control media flows, but also avoided raw surfaces, empty spaces and sharp edges in order to prevent the formation of air bubbles. A transparent window also enables visual inspection.

The dosing units can be conveniently scaled, and the jointly developed system is also so versatile that it can be used in any model of the BA-400 analysis device, making it a genuine one-for-all solution. The result of the close partnership was a system that impressed as much with its low water and material consumption as it did with its precision.

“Despite the new challenges and difficulties normally occurring with innovative developments, the two partners succeeded together in working out a forward-looking solution,” said BioSystems Mechanics Manager Francesco Grau.

By combining core competencies, a tailored one-for-all dosing unit was implemented into the new analysis instrument, meeting the complex and indispensable requirements of clinical diagnosis while optimising internal cost structures and flexibility.

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