Malvern NanoSight with nanoparticle tracking analysis concentration measurement upgrade

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The Malvern NanoSight provides an easy-to-use, reproducible platform for nanoparticle characterisation. Using nanoparticle tracking analysis (NTA), single particles can be measured for size and concentration.

A wide range of applications can benefit from NTA analysis, including nanoparticle production, nanoparticle toxicology, exosome and micro vesicle research, protein aggregation, drug delivery and vaccine development. A fluorescence mode also enables detection of labelled particles.

Benefits of NTA include minimal sample preparation, visual validation of results and user-friendly software with easy set-up of SOPs for routine use. The high-resolution particle sizing technique is suitable for polydisperse systems.

Driven by the growing popularity of the technique, an upgrade has been developed. Measurement of concentration has been modified to reduce user input, reduce variability and provide interlaboratory consistency in size and concentration measurements.

The upgrade has enabled improved robustness, precision and reproducibility of concentration measurement on a wide range of nanoparticle types for a broad size and concentration range. It can be coupled with DLS to extend the measurement range to below 1 nm and measure particle stability (or zeta potential). The upgrade is available for NS300 and NS500 systems and requires a syringe pump and NTA 3.1 software.