Malvern Panalytical Spraytec for aerosol and spray characterisation

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The nasal passage, commonly used to deliver decongestants and anti-inflammatory steroids, can provide a direct route for fighting infection from disease-causing pathogens like viruses, including SARS-CoV-2. The nasal route offers a possible alternative to oral or injection methods for the delivery of vaccines. The large surface area for absorption in the nose and lungs, coupled with the high density of blood vessels, allows for rapid onset of action as well as avoiding enzyme degradation within the GI tract.

The droplet or particle size delivered by the spray pump is an important parameter in defining the drug deposition site within the lung and nasal passages. The design of the pump as well as drug formulation properties like viscosity, rheology and surface tension can influence the droplet size produced. If the droplet size is too fine, there is a possibility that the particles will pass through the nasal passages and deposit in the lungs. On the other hand, if the droplet size is too large, the spray may be trapped in the nostrils.

The Malvern Panalytical Spraytec is a laser diffraction-based particle size analyser and is designed with a measurement rate fast enough to characterise sprays and aerosols in real time. Used to investigate the performance of nasal sprays, nebulisers and inhalers, it is designed to provide accurate data for even highly concentrated spray plumes.

The Nasal Spray Actuator accessory can help in the elimination of operator bias during bioequivalence studies. Monitoring the effect changes in the force applied during actuation of a device can aid in the development of new efficient devices and formulations.

The Spraytec system is easy to use with single-click, SOP-driven operation and user-friendly software for effective data interpretation.

For more information: https://www.atascientific.com.au/products/malvern-spraytec/.