Malvern Zetasizer Advance range for nanoparticle size and concentration

Click2Contact

The Zetasizer Advance family of light-scattering instruments offer the versatility to deliver fast and comprehensive particle size analysis. Combining novel measurement capabilities together with an artificial intelligence (AI)-led approach to data quality assessment, the Zetasizer systems are designed to help gain more insight and further confidence to characterise size and surface charge of colloids and biomolecular nanoparticles; screen protein formulations for colloidal stability and the presence of aggregates; and assess the shelf life and stability of complex formulations.

Building on the legacy of the Zetasizer Nano series, the three core models — Zetasizer Lab, Zetasizer Pro and Zetasizer Ultra — can be tailored and quickly upgraded to suit specific application needs. The Zetasizer Advance range offers particle size (from below 1 nm to 10 µm), particle charge (zeta potential) and particle concentration analysis. In addition, each benefits from the below advances.

A data acquisition algorithm, featuring adaptive correlation, uses a statistically driven approach to produce the best correlation data, without the need for sample filtering, to deliver fast size measurements and add confidence to the results. Multi-angle dynamic light scattering (MADLS) meanwhile enables calibration-free measurement of particle concentration.

Novel constant current zeta mode allows for high ionic strength measurements previously not achievable. Improved zeta sensitivity requires much lower sample concentrations for a zeta measurement, saving precious material.

AI-guided data quality advice allows even a novice without any prior light scattering knowledge to make sense of sizing data. A novel 3 μL low-volume size cell lowers sample volume and extends concentration range.

A fluorescence filter wheel allows for extended applications with fluorescent samples, like quantum dots. Polarisation filter as well as vertical and horizontal polarisation components can be detected, potentially offering insights into particle rotational diffusion.

There are more than 100,000 publications using the Zetasizer. The product also works with OmniTrust, Malvern Panalytical’s compliance solution for the regulated environment.

For more information: https://www.atascientific.com.au/products/zetasizer-ultra/.