Micropore Technologies Pathfinder series for efficient nanoparticle creation

Click2Contact

The Micropore Technologies Pathfinder series, using Advanced Cross Flow (AXF) mixing technology, has been designed to create nanoparticles efficiently and with minimal effort. While many turn to readily available lipids to assess size, PDI and encapsulation efficiency (EE), Micropore can encapsulate RNA beyond 99%.

The development of treatments is changing; research institutes and smaller biotech organisations are demanding scale much like traditional CMOs, CDMOs, lipid manufacturers and pharmaceutical companies across the globe. The Micropore Pathfinder and Horizon series encompasses both research and production requirements accommodating this emerging requisite.

The capacity to be customisable to a given formulation means the system can pivot to the formulation rather than changing the formulation to fit a technology. Additionally, the formulation conditions can scale on the same mixer from microlitres to litres of production — even thousands of litres.

The ever-increasing numbers of microfluidic mixers (MF) introduced to the market tend to be specific to a formulation construct; they can require months of research and development to make the required formulation work on the MF device. Another concern is that MF devices cannot scale efficiently; physics precludes it. There are a few that try altering the flow dimensions of the MF devices; however, this is limited in volume and frequently involves manipulation to the base formulation, potentially risking exposure to regulatory authority implications.

The Micropore Technologies Pathfinder range has packages that are suitable for all steps in the formulation journey. For those early in their campaign, the Pathfinder Pro 125 might suit the formulation discovery path. For those who already have a formulation and wish to transition to clinical trials, consider the Pathfinder Pro 250. Furthermore, a small Horizon system is suitable for GMP environments. The technology is flexible enough that there should be a fit for any paradigm.

For more information, visit https://www.atascientific.com.au/products/axf-pathfinder/. Interested parties can also consider a demonstration of the Pathfinder in their facility to experience the scope of the technology with their formulation.