Adixen Lyotrack online moisture measurement system

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Adixen’s Lyotrack, an online moisture measurement system for freeze dryers, is designed to monitor the water vapour concentration under vacuum conditions inside a freeze dryer.

Previously, online monitoring of a freeze-drying process has been done by measuring temperature, pressure and time. With a careful interpretation of these three parameters it is possible to determine the end of the primary and secondary drying phases. With large production freeze dryers, placing the temperature probes and wiring up the connections throughout the freeze dryer is a protracted task. Results can vary from user to user simply through inconsistent placement of the temperature probe within the chamber or sample.

Unlike temperature measurements with just a few probes spread throughout the freeze-drying chamber, the Lyotrack is able to measure the complete load, independent from quantities or the product location within the freeze dryer. The system uses ICP- OES technology (inductively coupled plasma - optical emission spectroscopy) to directly measure the water vapour inside the freeze dryer. Not only does it allow an instant measurement of product moisture levels, it also helps in the determination of process parameters such as the end of primary and secondary drying stages.

Installing is straightforward - the system uses a flange connection on the freeze dryer which only involves minor modifications if not yet present. The monitoring software runs off any standard Windows PC.

The system complies with FDA recommendations, including the Process and Analytical Technology (PAT) initiative recommending modern process analysis tools and resources for monitoring and controlling processes and process endpoints.