Sartorius Sartopore Platinum sterilising-grade filters

Sartorius Stedim Biotech has announced the sterilising-grade filters Sartopore Platinum. The surface of the polyethersulfone filter membrane has been modified using a hydrophilic and highly thermostable polymer, giving the membrane good wetting properties and minimising its protein binding. Fewer than 5 L of water for injection (WFI) are needed to wet a 10″ cartridge fast and reliably for subsequent integrity testing that provides accurate results.

The membrane’s minimised protein binding increases product yield, thus augmenting the efficiency of manufacturing processes. The filter cartridges can be dry-steam sterilised in the forward or the reverse direction, without altering the properties of their membrane. These sterilising-grade filters can be used in the entire pH range from 1 to 14 and thus for nearly any filtration application in biopharmaceutical manufacturing.

The membrane of the filter cartridges has been pleated using the company’s TwinPleat process. The alternating long and short pleats of the membrane increase the filter area of a 10″ cartridge by more than 60%. At the same time, this geometry ensures that liquids flow through the entire filter area so that the filtration capacity of the cartridge is used to the fullest extent. As a result, the filter cartridges boost filtration performance and lower filtration costs.

The product is available in a choice of different sizes and constructions, ranging from lab to production scale. In all sizes, identical materials of construction with consistent performance characteristics are used.