EXODUS BIO automatic exosome isolation system for high speed, purity and yield

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The EXODUS series of automatic exosome isolation systems represents an advanced technological approach for laboratories engaged in extracellular vesicle (EV) research, particularly those focused on exosomes.

Exosomes — nanometre-scale EVs with key roles in cell–cell communication — have gained prominence due to their potential as biomarkers for disease diagnostics and as vehicles for therapeutic delivery. But traditional methods for exosome isolation — such as ultracentrifugation, precipitation and size-exclusion chromatography — are labour-intensive and pose multiple challenges, including low yield, variable purity and susceptibility to sample degradation, which limit reproducibility and scalability.

The EXODUS BIO automatic exosome isolation system is designed to minimise manual handling, reducing variability and enabling consistent, high-purity yields across a range of biological fluids, including serum, plasma, urine and cell culture media. This facilitates the preservation of exosomal structural integrity of bioactive molecules, which is important for downstream applications including molecular profiling and drug delivery studies.

The EXODUS has been developed using a dual-membrane nanofiltration system that integrates periodic negative pressure oscillation (NPO) and double-coupled ultrasonic harmonic oscillations (HO). The exosomes are intercepted by a nanoporous membrane, while free nucleic acid and protein impurities are removed from the sample, resulting in the efficient purification and enrichment of exosomes.

The product is suitable for labs aiming to scale up exosome research while maintaining rigorous standards in quality and reproducibility. It eliminates challenges associated with traditional ultracentrifugation, making exosome isolation more accessible and efficient. Researchers can thus expect enhanced workflow efficiency and the capacity to drive new discoveries in the rapidly expanding field of EV research.

For more information, visit https://doi.org/10.1038/s41592-020-01034-x or https://www.atascientific.com.au/products/exodus-automatic-exosome-isolation/. To request a demo, contact ATA Scientific.