Enzo Life Sciences TIMP-1 (human) ELISA kit

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Tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of the four members of the TIMP family which inhibit the activity of the matrix metalloproteinases (MMPs), a large group of peptidases involved in degradation of the extracellular matrix. TIMP-1 displays multiple biological functions and is capable of inhibiting the activities of most MMPs except membrane-type MMP subfamily.

Associated with its inhibitory activity on MMPs, TIMP-1 is able to promote cell proliferation and survival in a wide range of cell types. Recent findings have separated the MMP inhibitory activity of TIMP-1 from its growth-promoting effect. TIMP-1 exhibits growth factor-like activity and acts as a cell survival factor which may be mediated through ligand-receptor interactions.

The balance of TIMPs/MMPs plays a crucial role in extracellular matrix homeostasis and remodelling; the imbalance of TIMPs/MMPs is involved in various kinds of diseases in multiple organs. Breaking the balance between MMPs and TIMPs occurs in various pathologic processes and involves all the members of these two families.

The Enzo Life Sciences TIMP-1 (human) ELISA kit enables sensitive measurement of TIMP-1 in just 2 h, detecting as little as 30 pg/mL. There is negligible cross reactivity with similar proteins and its high-throughput format is suitable for up to 39 samples in duplicate.

The product provides fully quantitative results which are said to surpass semi-quantitative Western blot analysis. It is suitable for research areas including amyotrophic lateral sclerosis (ALS), obesity, cancer, diabetes, cardiovascular disease, renal disease, chronic inflammation and systemic scelerosis.

For more information: http://www.enzolifesciences.com/ENZ-KIT147.