Wyatt Light Scattering DynaPro plate reader

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The Wyatt Light Scattering DynaPro plate reader can perform accelerated stability, thermal melting and temperature studies on multiple samples in parallel.

With good high-throughput dynamic light scattering performance, the non-invasive technology measures samples directly from industry-standard microplates (96, 384 or 1536 well plates) using as little as 5 µL/well. After the plate is loaded into the DynaPro, the data are collected automatically, in an unattended manner, by the Dynamics software, which supports full integration with liquid-handling robotics. Once the data are collected the samples can be recovered and the plates discarded, with no cleaning required.

The DynaPro is claimed to increase productivity by a factor of 10 or more when sizing biomolecules and other nanoparticles compared to conventional batch dynamic light scattering (DLS) systems.

Samples can be loaded in duplicate or triplicate and scanned several times by the plate reader, providing data that are a true measure of sample repeatability and reproducibility. Due to the low sample volumes and automated capability, these experiments can be performed in less time and without the difficulties of conventional batch DLS, with users able to explore a larger number of solution conditions or protein or other nanoparticle constructs.

Suitable applications include: bioprocessing and quality control of viral particles and vaccines; screening proteins prior to crystallisation trials; exploring antibody formulations over a broad range of solution conditions; and characterising stable protein formulations.