Enzo Life Sciences SUPERKILLERTRAIL protein (soluble) (human), (recombinant)

Enzo Life Sciences’ SUPERKILLERTRAIL protein (soluble) (human), (recombinant) is an enhanced ligand that utilises the Killer linker peptide mutated to increase disulfide-mediated cross-linking to form a more stable oligomer.

It has been well established that signals transmitted via TNF ligands and receptors are critical in mediating inflammation, cancer and immunity. This has led to drug development aiming to either reduce or enhance receptor response. One limitation in this process is the inherent instability of recombinant ligands and their inability to effectively mimic the natural clustering of TNF receptors on the cell surface required for immune activation. According to Enzo Life Sciences, oligomerisation of TNF ligands such as SUPERKILLERTRAIL has been shown to improve stability and enhance immune activation compared to recombinant ligands alone.

The product is available for research use only.