GeneCopoeia premade labelled cancer cell lines

In vivo monitoring of tumour growth and metastasis provides a powerful means for studying cancer properties and the development of effective therapies. Mouse models created with tumour xenografts have long been used for such purposes; however, without a convenient means to visualise cancer progression in these animals, invasive surgical procedures are required in order to estimate the size and weight of primary and metastatic tumours, and cannot be used for early stages in tumour development.

GeneCopoeia’s premade labelled cancer cell lines are either dual-labelled with luciferase and GFP or single-labelled with GFP. Robust luciferase expression permits sensitive, non-invasive detection of cancer cell growth and progression in vivo, beginning soon after injection. In addition, GFP expression is useful for in vivo tumour monitoring without the need for substrate perfusion, or for in vitro visualisation and immunocytochemistry.

Users can choose from among 34 premade lines with dual labels or 12 for the single label; tumour types include breast, liver, pancreas and colon. Applications include the study of tumour cell properties using biochemical and genetic methods in vitro and to monitor tumour growth, progression and metastasis in vivo in response to a variety of environmental stimuli, drugs and other therapeutic treatments.