Lonza PyroCell MAT Rapid System and PyroCell MAT Human Serum (HS) Rapid System

Lonza has launched two rapid monocyte activation test (MAT) systems, the PyroCell MAT Rapid System and PyroCell MAT Human Serum (HS) Rapid System, to streamline and simplify rabbit-free pyrogen testing. The systems, which will replace Lonza’s current MAT system kit offerings, contain the PeliKine Human IL-6 Rapid ELISA Kit, which minimises hands-on time and reduces time to results. The updated tests are designed to give pharma manufacturers easier, faster and more efficient MAT testing options for product safety testing while helping to reduce the reliance on animals.

Historically, pyrogen testing of pharmaceuticals has relied on the rabbit pyrogen test (RPT), an unsustainable method requiring significant time to results. Pharma manufacturers now face growing pressure to discontinue the RPT due to ethical concerns, regulatory initiatives and directives to increase the efficiency of QC pyrogen testing programs.

Lonza’s PyroCell MAT Rapid Systems, with the PeliKine Human IL-6 Rapid ELISA Kit, help streamline QC testing workflows. The ELISA kit contains pre-coated plates and an improved protocol with combined incubation steps, minimising hands-on time and reducing time to results from two days to just 2 h. The rapid ELISA kit results are comparable to the current industry standard, the company claims, making switching to the updated test simple for users. The rapid ELISA kit has been specifically validated for use with the MAT.