Lonza PyroTec PRO for automated endotoxin detection

The PyroTec PRO, from Lonza, is a fully automated, plate-based robotic solution for endotoxin detection. Integrated with the latest version of Lonza’s dynamic control WinKQCL 6.0 Software platform, the system has been designed to meet the needs of rapidly changing requirements of QC testing laboratories for fully automated processing of simple to complex sample matrices.

As a powerful combination of robotic liquid-handling technology with an automation software module, the system is designed to improve data integrity organically with the capture of metadata from the automated preparation, adding traceability into tracking, trending and audit controls. It takes any new and existing templates and dynamically ‘scripts’ the instructions to an automation template with relatively minimal effort from the end user, regardless of how complex the sample type or testing requirements.

The product is said to enhance assay robustness and reproducibility for increased confidence in the precision of results; reduce manual intervention, simplifying QC testing workflows and eliminating the human error potential; and reduce retest rates as well as out-of-specification and out-of-trend deviations, thereby improving the laboratory’s performance. It provides efficient endotoxin testing regardless of the complexity of sample/diluent types and analytical requirements.

The device integrates with laboratory information management systems or Lonza’s MODA Solution, facilitating fully paperless workflows and traceability of sample life cycle. Unlike conventional cartridge-based systems, it does not require the use of expensive reagents. It aligns with the US FDA’s Process Analytical Technology Initiative and Data Integrity requirements and is fully compliant with the US Pharmacopeia Bacterial Endotoxin Test guidance.