Mutagenicity assay kits

The Ames II, Ames MPF 98/100, Ames MPF 1535 and Ames MPF 1537 kits can be used to perform the Ames test in the liquid 384-well microplate format with a colorimetric read-out.

The Ames II assay differs from the Ames MPF assays in that it comprises TA98 and TAMix, consisting of six histidine mutant Salmonella tester strains, TA7001-TA7006. Each of these mutants can be reverted only by a specific transition or transversion, so that all possible base-pair changes can be detected by TAMix.

Tests can be automated on robotics systems for mass screenings, with easy interpretation and calculation of results and no inter-assay variability from variations in cell composition, activity and density. Quality controlled reagents add to the overall consistency.

These ready-to-use kits include all reagents necessary to perform the Ames test and are claimed to have reduced hands-on time and generate less waste than the traditional assays.