Enviromimetics and schizophrenia pathways

Scientists at Melbourne's Howard Florey Institute have shown that mental and physical exercise can improve behavioural deficits in schizophrenia and repair damaged chemical transmitter pathways in the brain.

Dr Anthony Hannan, along with Dr Caitlin McOmish, Emma Burrows and colleagues, characterised a genetically altered mouse and discovered that it had schizophrenia-like behaviours, including learning and memory problems, the inability to process complex information, and abnormal responses to particular sensory stimuli.

The scientists found the mouse's condition significantly improved by simply giving them enhanced mental and physical exercise - putting running wheels in their cages, plus interesting items to smell, see and touch.

Not only did the mouse's schizophrenia-like symptoms ease through this environmental enrichment, but a specific chemical transmitter pathway found to be abnormal in the cerebral cortex of the mice was selectively rescued.

An anti-psychotic drug used by humans also improved the mouse's condition, indicating that this mouse is a valid model for schizophrenia in humans.

Hannan said this discovery could pave the way for the development of better treatments for schizophrenia.

"Through our research, and that of others, we hope a new class of therapeutic drugs will be developed that mimic the effects of environmental enrichment in the brain to treat various brain disorders, possibly including schizophrenia," Hannan said.

"Pharmaceutical approaches may not be the sole answer for a given brain disease. People may still need optimal levels of physical and mental activity, as well as a healthy diet, plus the right drugs.

"We have already identified specific molecules that could be targets for what I call 'enviromimetics' and these may have relevance for other brain diseases.

"However, there are obviously major differences between mice and men, and large-scale clinical trials are needed to identify the most beneficial drugs," he said.

At only 37 years of age, Hannan is internationally recognised for his Huntington's disease research and was awarded a $1 million Pfizer Australia senior research fellowship to fund his ongoing environmental enrichment studies.

This research, which also involved collaboration with scientists from the Mental Health Research Institute of Victoria, is currently an advanced online publication of the international journal Molecular Psychiatry.

Source: Howard Florey Institute