Potential test for diabetes in children

Source: University of Queensland

University of Queensland researchers are developing a simple test that may predict whether a child will develop type 1 diabetes.

Professor Ranjeny Thomas and her colleagues from UQ's Diamantina Institute for Cancer, Immunology and Metabolic Medicine have identified a cellular pathway known as NF-kappa B that is activated in blood cells of people with type 1 diabetes.

"Blood cells are the major infection and immune-control cells of the body, called monocytes and dendritic cells," Thomas said.

"Monocytes from healthy people are 'quiet' in the blood and if we expose them to infection outside the body, the NF-kappa B pathway gets activated.

"In individuals with type 1 diabetes, we found monocyte NF-kappa B was already activated in the blood, and when exposed to infection the pathway shut down. This tells us something fundamental about the problems of immune control that cause diabetes to develop in children.

"As a spin off, by simply taking blood, we hope to now be able to identify if a child will develop diabetes."

She said the test would target families with a history of diabetes with the aim of picking up other children at risk.

"Currently available tests pick up this risk rather late and in relatively few people, when there is already evidence of intolerance of the pancreas," she said.

"We are investigating at what stage our test becomes abnormal.

"With various trials of vaccines for diabetes underway, the potential is there to identify and intervene in children at risk of type 1 diabetes before it occurs.

"But what is also important, is that we are in a position to really investigate why the immune system loses control before the disease starts. That fundamental understanding will bring the vaccines of the future."

The research has been published in the Journal of Immunology.