Pregnancy complications increase heart disease risk

Certain complications during pregnancy bring an increased risk of heart disease later on; however, there is still much to learn about how arteriosclerosis develops between pregnancy and heart disease later in life. A new study from Swedish researchers now shows that narrowing and calcification of the blood vessels of the heart are more common in women previously affected by pregnancy complications.

The researchers included 10,528 women from the National Medical Birth Register who have subsequently gone on to participate in the large population study SCAPIS (Swedish Cardiopulmonary Bioimage Study) at age 50–65 years. All the women underwent CT scanning of the coronary arteries (coronary computed tomography angiography) in order to detect calcification of blood vessels, narrowing and other signs of heart disease. The researchers investigated signs of heart disease by history of five common complications in pregnancy — pre-eclampsia, high blood pressure during pregnancy (gestational hypertension), preterm delivery, gestational diabetes and infants born small for gestational age — with their results published in JAMA.

They found that 4% more of the women with pregnancy complications had visible atherosclerosis of the coronary arteries, compared to the group who had not had complications in pregnancy (32% as opposed to 28%). The greatest link was for pre-eclampsia and gestational hypertension. Among women who had not experienced any complications in pregnancy, 2% had narrowing in coronary arteries while the corresponding number among women who previously suffered from pre-eclampsia or pregnancy-induced hypertension was 5%.

“Our results suggest that the correlation exists even among women with a low expected risk of cardiovascular disease,” said Associate Professor Simon Timpka from Lund University, who led the research team. “The study is an important piece of the puzzle in understanding how women with pregnancy complications should be followed up by their healthcare provider after pregnancy.”

“To reduce the risk of these women developing coronary heart disease in the future, it is important that they check risk factors such as blood pressure, blood sugar and cholesterol regularly,” added study co-author Sofia Sederholm Lawesson, a consultant cardiologist at Linköping University Hospital.

Timpka acknowledged that the study investigated many different associations between complications in pregnancy and heart disease all at once, so it is possible that chance might explain individual results. “Yet the pattern is relatively consistent, which makes it easier to draw conclusions including that women with prior pre-eclampsia have changes in the coronary arteries that are equivalent to the changes seen in women who have not experienced complications in pregnancy but are 5–10 years older,” he said.

According to Timpka, CT scans of the coronary arteries are increasingly used in patients presenting with symptoms, but there is still a lack of large studies into the significance over time of some of the studied changes among women without current symptoms. He concluded, “Even if our study provides new knowledge on the development of coronary heart disease among middle-aged women who have previously suffered complications in pregnancy, there is a need for long-term studies in order to understand the true meaning that our discoveries have for symptomatic disease.”

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