Sartorius Biostat STR bioreactor with Repligen XCell ATF technology

Sartorius and Repligen Corporation have launched an integrated bioreactor system that incorporates Repligen XCell ATF upstream intensification technology into Sartorius’s Biostat STR bioreactor, simplifying intensified seed train and N perfusion implementation for biopharmaceutical manufacturers with a single direct control interface.

The bioreactor contains a fully compatible embedded XCell ATF hardware and software module offering predefined advanced control recipes with integrated process analytical technology (PAT). This system gives users a streamlined way to control cell growth and improve cell retention in perfusion processes without using a separate cell retention control tower. The integrated product thus provides a simplified, easy-to-implement perfusion-enabled bioreactor solution for efficient, higher-density cell culture processes.

Users can also better utilise facility space with a reduced equipment footprint from the incorporation of the XCell Controller hardware and software in the Biobrain automation platform, creating a single point of control for 50–2000 L upstream intensification processes. The single, integrated controller provides easy integration into SCADA and DCS.