Method for determination of crotamiton
Thermo Fisher Scientific has developed an efficient quality control method for the determination of the cis and trans isomers that comprise crotamiton, used in the treatment of scabies and skin pruritus. The method is more efficient than the official protocols of the British Pharmacopoeia (BP) and Pharmacopeia of the People’s Republic of China (PPRC).
The method involves a convenient reversed-phase high-performance liquid chromatography (RP-HPLC) using a Thermo Scientific Acclaim C30 column with a simple acetonitrile/water mobile phase. The column is designed to provide high shape selectivity for separation of hydrophobic, structurally related isomers and selectivity complementary to other RP columns (eg, C18).
Although another method for analysis of cis and trans isomers of crotamiton by RP-HPLC has been reported, it requires a three-component mobile phase (acetonitrile/phosphate buffer containing 1% triethylamine) to achieve satisfactory results.
This application can be found at www.thermoscientific.com/dionex under the Documents tab.
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