Researchers find protein protecting against STIs

Monash Institute of Medical Research (MIMR) scientists have found a protein in the female reproductive tract that protects against sexually transmitted diseases (STIs) such as chlamydia and herpes simplex virus (HSV).

The research, published today in the prestigious journal Science, was led by Professor Paul Hertzog, Director of MIMR’s Centre for Innate Immunity and Infectious Diseases, and his team including Ka Yee Fung and Niamh Mangan.

The team discovered a protein, which they called Interferon epsilon (IFNe), and showed it plays an important role in protecting females against infections. It could have clinical potential to determine which women may be more or less susceptible to diseases such as STIs or to boost protective immunity.

IFNe could also be used potentially to treat STIs or other inflammatory diseases.

“One way this protein is unusual is because of the way it’s produced,” Professor Hertzog said. “Most proteins protecting us against infection are produced only after we’re exposed to a virus or bacteria.

“But this protein is produced normally and is instead regulated by hormones, so its levels change during the oestrous cycle and is switched off at implantation in pregnancy and at other times like menopause.

“Some of these times when normal IFNe is lowest correlate with when women are most susceptible to STIs, so this might be an important link to new therapeutic opportunities. IFNe follows different rules to normal immunomodulatory proteins, and therefore this might also be important to vaccines and the way they’re formulated to boost our protective immunity.

“Since this protein boosts female reproductive tract immune responses, it’s likely, although we haven’t addressed it directly, that this finding will be important for other infectious diseases like HIV and HPV and other diseases.”

Professor Hertzog said STIs are a critical global health and socioeconomic problem.

It is estimated that 450 million people worldwide are newly infected with STIs each year. According to the 2011 Australian Bureau of Statistics, chlamydia has the highest infection rate of the notifiable STIs and infection rates have more than tripled over the past decade. Men and women in the 15- to 19-year age group saw the largest increase in infection rates. According to these statistics, chlamydia affects more women than men.

Professor Hertzog said the next step for this research would be to work towards clinical studies within the next five years. He is also keen to see whether this work can be applied across other diseases including cancer, female reproductive tract-related disorders including endometriosis and pelvic inflammatory disease, as well as other non-reproductive tract diseases.

This research was carried out in collaboration with partners at other departments of Monash University, the University of Newcastle, University of Adelaide, Peter MacCallum Cancer Centre and the University of Oklahoma.