Rare human antibody protects against AIDS
Monday, 24 September, 2001
Scientists have obtained their first detailed glimpse of a rare antibody, called B12, which is capable of inactivating many different strains of human immunodeficiency virus, the germ which causes AIDS (acquired immune deficiency syndrome).
A crystal structure of B12 has been determined by scientists working at the Glycobiology Institute at Oxford University, England, and the Scripps Research Institute in California, US, which shows that the antibody has a long finger-like region on its surface that is able to penetrate the surface of the HIV germ and prevent it causing disease. It is hoped that the structure of this region may provide a basis for the design of effective vaccines against HIV.
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