Research identifies enzyme involved in fat storage

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Sunday, 14 July, 2002

Howard Hughes Medical Institute researchers pursuing the cause of leptin's ability to boost metabolism and shed fat have identified a metabolic switch that appears to tell the body to store or burn fat.

Using DNA microarrays, the researchers looked for specific genes in the liver that are under the control of leptin.

One of the genes under leptin's influence expresses the enzyme SCD-1. Additional studies showed that when leptin is absent, the level of SCD-1 rises and more fat is stored in the liver.

Item provided courtesy of The Howard Hughes Medical Institute

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