Thermo Scientific Vanquish Method Development HPLC and UHPLC system

Thermo Fisher Scientific and ChromSword have collaborated to launch an automated high performance liquid chromatography (HPLC) and ultrahigh-performance liquid chromatography (UHPLC) method development system that enables chromatographers to deliver robust and validated methods in minimal time and with high confidence.

The Thermo Scientific Vanquish Method Development HPLC and UHPLC system provides an integrated, network-deployable solution for automated method development and validation for diode-array, charged aerosol and mass spectrometric detection. Built for ease of use and speed, the system strategically combines the Vanquish HPLC and UHPLC systems and the Thermo Scientific Chromeleon Chromatography Data System (CDS) with ChromSwordAuto and ChromSword AutoRobust software. It leverages artificial intelligence to minimise manual interaction and enables method creation for complete compound detection with no prior sample knowledge required. It offers multiple detection capabilities, and the integrated Chromeleon Data Vault further reinforces data integrity and compliance.

In addition to speed and ease of use, the system offers method flexibility to pharmaceutical, biopharmaceutical, chemical and food testing laboratories, featuring automated column switching and universal analyte detection, with mass spectrometry-based peak tracking capabilities delivering correct results. Using Chromeleon CDS with ChromSwordAuto Chromeleon Connect and ChromSword AutoRobust Chromeleon Connect enables chromatographers to automate method development tasks, including method scouting, impurity profiling, fine optimisation and method validation. Through next-generation automation, the system can be used to meet the changing needs of laboratories as they look to implement digitalisation strategies and reduce onsite personnel.