Uterus transplant safe and effective at combating infertility

Transplanting a uterus is an effective and safe method to remedy infertility when a functioning uterus is lacking, according to the first known complete study of uterine transplantation.

The study, published in the journal Fertility and Sterility, covers transplantation of uteri from living donors. The operations were headed by Mats Brännström, Professor of Obstetrics and Gynaecology at Sahlgrenska Academy, University of Gothenburg, and Chief Physician at Sahlgrenska University Hospital.

After seven of the study’s nine transplants, IVF treatment ensued. In this group of seven women, six (86%) became pregnant and gave birth. Three had two children each, making the total number of babies nine. The probability of pregnancy per individual embryo returned to a transplanted uterus was 33%, which is no different from the success rate of IVF treatments overall.

“This is the first complete study that’s been done, and the results exceed expectations in terms both of clinical pregnancy rate and of the cumulative live birth rate,” Brännström said.

“The study also shows positive health outcomes: the children born to date remain healthy and the long-term health of donors and recipients is generally good too.”

The first birth after uterine transplantation took place in Gothenburg in 2014. Another seven births followed, within the framework of the same research project, before anyone outside Sweden gave birth following uterine transplantation.

The research group has since passed on its methods and techniques through direct knowledge transfer to several research centres outside Sweden. By year-end 2021, the number of uterine transplants in the world was estimated at 90, of which 20 had been performed in Sweden. Worldwide, some 50 children have been born after uterine transplantation.

Most of the research groups around the world contribute data on donors, recipients, transplants, births, complications and other information to the international uterus transplant register, which was initiated and is maintained by the Gothenburg researchers. This register, under the aegis of the International Society of Uterus Transplantation (ISUTx), is expected to be a highly valuable research instrument in the future, serving to make the procedure even safer and more efficacious.

Image credit: ©stock.adobe.com/au/famveldman

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