Parse Biosciences Evercode BCR kits for mouse samples

Parse Biosciences, a provider of scalable single-cell sequencing solutions, has expanded its Evercode BCR product line to enable applications in mice. The new kits enable researchers to profile the mouse BCR repertoire alongside whole transcriptome data for millions of cells in a single experiment, offering scale and efficiency for antibody discovery.

The Evercode BCR platform is designed to streamline workflows for antibody research, allowing scientists to identify individual antibody-producing cells and their clonally related groups that generate specific antibodies of interest. Novel features, such as sample fixation capabilities, allow researchers to preserve cells and samples from mice for up to six months, thereby reducing the need to harvest additional mice and maximising the yield per discovery campaign. Furthermore, the technology eliminates the requirement for additional equipment, making advanced single-cell analysis accessible with standard laboratory tools.

The product delivers comprehensive profiling of BCR clonotype diversity and VDJ gene usage frequencies, while its high pairing rate for the immunoglobulin heavy and light chains results in accurate antibody analysis. Additionally, it is useful for detecting rare populations, such as plasma cells, preserved through gentle fixation and advanced combinatorial cell barcoding techniques.

With the expansion of the platform to support studies in mice, researchers can comprehensively characterise the immunological responses in disease-specific mouse models and accelerate their antibody discovery efforts. This is expected to have a positive impact on the field of immunology and antibody-based drug discovery.